Natuzzi section instructions on how to tie

Antibody or antibody fragment for use in a method of reducing a cholesterol level or maintaining a previously reduced cholesterol level in a human being in need thereof, the method comprising administering the antibody or fragment to the human being, the antibody or fragment being a proprotein Convertase, subtilisin / kexin type 9 (PCSK9), which specifically binds a C-terminal domain comprising a mutation I474V, E670G, N425S or Q619P in SEQ ID NO: 1 and wherein the antibody or the fragment is a human lambda IGLC2 * 01 light chain constant region includes
and
being man
(i) an IGLC2 * 01 human lambda chain constant region gene segment, or the human expresses antibodies comprising lambda light chain IGLC2 * 01 constant regions, and
(ii) comprises a nucleotide sequence encoding proprotein convertase, subtilisin / kexin type 9 (PCSK9), which encodes a C-terminal domain comprising the mutation in SEQ ID NO: 1.